ACTIVE INGREDIENT: ANASTROZOLE
Arimidex, which is anastrozole - is prescribed for women in the post-menopausal period of widespread breast cancer. As exception can be patients with estrogen negative cancer if only earlier they didn't have a positive clinical answer on tamoxifen. For adjuvant therapy at the patients in the post-menopausal period having the positive indicators of receptor of hormone, an invasive estrogenpositive breast cancer at early stages. For adjuvant therapy at patients in a post-menopausal period who had adjuvant treatment by tamoxifen within 2-3 years, estrogen of a positive breast cancer at early stages.
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|1mg X 30 Pills||$6.57|| |
+ Bonus - 4 Pills
|1mg X 60 Pills||$5.25|| |
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Arimidex: instructions, composition, indications, action, reviews and prices
Arimidex (Anastrozole) is prescribed for the treatment of breast cancer. It is an antineoplastic agent with hormonal activity. It is prescribed in oncological practice only for adult patients. It can be used as monotherapy or together with other medicines.
The drug is included in the list of the safest and most effective medicinal substances according to the World Health Organization.
|Differences between an online pharmacy and a city pharmacy:|
|1. You can only look at the goods, but you cannot touch, smell, try on;|
|2. We do not receive purchases immediately, but wait for some time until they are delivered to us by courier or mail;|
|3. Payment is most often made immediately, but in some stores you can pay for the order upon receipt.|
Buying drugs online has its advantages and disadvantages, we will talk about them later, but now we will figure out what is needed in order to successfully place your first order of the drug Anastrozole 1 mg.
Pay attention to the terms of delivery, payment and return of goods, as well as contact information. Usually all this information is publicly available on the seller's website. If not, check these questions with your consultant.
Safe online shopping for Arimidex
The most important thing for buyers on the Internet is to avoid encounters with fraudsters, which are becoming more and more, and they by any means want to steal information from us and steal money.
Therefore, we advise you to always follow these rules for safe online shopping:
1. Use your computer and secure internet connection.
2. Install a good antivirus, it will help protect payments and all your online activities.
3. Make sure that you have entered the correct web resource address, there are craftsmen who fake websites in order to steal data from you.
4. Make sure the online pharmacy where you want to shop is trustworthy. To do this, pay attention to the left corner, there should be a lock, this means that the data you enter here is encrypted and protected. If not, the risk of data loss increases.
5. For online transactions, you can create a separate bank card or account in the electronic money system for even greater security.
6. Be sure to read reviews of the online pharmacy.
7. Clarify all questions with consultants before ordering and paying for your purchase.
8. Connect to the bank card with which you pay for orders in the network, SMS-confirmation of any payments.
Be careful and do not take risks by contacting unreliable resources, then the probability of losing money will significantly decrease and will tend to 0.
What is Arimidex 1 mg and what is it used for?
Arimidex belongs to a class of newer potent aromatase inhibitors available in tablet form. It was originally used in traditional medicine to treat breast neoplasms in female patients. At the moment, the drug has also gained significant popularity among representatives of various sports disciplines who use anabolic and androgenic steroids, which have a high tendency to aromatize, to improve their physical fitness.
The drug effectively eliminates gynecomastia, protects against excessive swelling, fluid retention and other estrogen-dependent side reactions that accompany the use of anabolic substances. Quite often, athletes who do not know what anastrozole is, confuse it with antiestrogens like clomid or tamoxifen. But this drug is completely different from them. Aromatase inhibitors, which include anastrozole, suppress aromatization processes, eliminate estrogenic side reactions from steroids, and are often used on the course. Antiestrogens are taken during post-cycle therapy, they allow the athlete's body to be restored after a course of steroids, including normalizing the production of natural testosterone.
What are the positive effects of Arimidex 1 mg?
Not all anabolic drugs are subject to conversion to estrogen in the body, anastrozole is used on the course of testosterone and its derivatives - methyltestosterone, methandrostenolone. Boldenone and halotestin are slightly aromatized. Also, before using an aromatase inhibitor, you need to be tested for estradiol to confirm the appropriateness of taking the drug.
|To finally understand what Arimidex is for, you need to learn about the main positive effects that this aromatase inhibitor has on the athlete's body, which include:|
|1. blocking the growth of the concentration of estrogen in the body;|
|2. prevention of high blood pressure, gynecomastia;|
|3. reduction of the suppressive effect of estrogens on the work of the hypothalamus-pituitary-testicles axis, which allows for a shorter period of time to restore the production of the male sex hormone in the body;|
|4. an increase in the concentration of anabolic hormones in the blood;|
|5. An aromatase inhibitor is an indispensable tool for athletes with a genetic tendency to aromatize.|
Arimidex is characterized by a rather pronounced effect on the body - one milligram of the active component of an aromatase inhibitor is enough to suppress 80% of estradiol in the blood from the initial values. It is also worth noting that the maximum concentration of the active ingredient occurs a couple of hours after taking the pill.
How to use the drug Arimidex 1 mg correctly?
Many beginners are interested in what Arimidex is, but it is worth noting that this aromatase inhibitor is taken mainly by professional athletes. The tablets of this drug can be taken both on the course of anabolic and androgenic substances, and during post-cycle therapy.
|Arimidex is used in two cases:|
|1. With the manifestation of estrogen-dependent side reactions from the use of anabolic and androgenic drugs - swelling of the mammary glands, redness, itching in the nipple area, it is necessary to take an aromatase inhibitor 1 mg - the whole tablet is used daily until the symptoms pass, then therapeutic doses are used;|
|2. For the prevention of adverse reactions, you need to drink 0.5 mg - half a tablet every other day.|
For both dosage regimens, the course should last no more than 2 weeks, such a period of use of anastrozole allows you to feel all the positive properties of the drug without the occurrence of adverse reactions. For better absorption of the active ingredient from the gastrointestinal tract into the blood, the tablets are best taken in the morning on an empty stomach with plenty of purified plain water.
The manifestation of a depressive state, problems with erectile function, and a decrease in libido may indicate that the dosage should be reduced. It should also be noted that a small level of estrogen in the male body has a positive effect on the development of muscle volumes, therefore, the prophylactic dose of anastrozole is indicated exactly in the amount that is needed to maintain the physiologically necessary level of estrogen for athletes.
What side effects do you need to be prepared for?
Arimidex is used primarily by men, as it can cause serious hormonal disturbances in women. In case of individual intolerance to the active component, exceeding dosages, prolonging the course of administration, the following undesirable reactions may occur:
|1||Frequent drowsiness, a state of general weakness, which can reduce the effectiveness of training;|
|2||Various allergic reactions, expressed in the form of skin rashes;|
|3||Diarrhea, bouts of nausea, vomiting;|
|5||Skin disease characterized by target-like burns.|
Also, too low a concentration of estrogen in the male body can lead to a slowdown in muscle development, frequent joint pain, a decrease in bone strength, an increase in the concentration of "bad" cholesterol in the blood, which is fraught with heart disease. Because of this property, an aromatase inhibitor should be used with extreme caution by athletes with cardiovascular disease.
After examining the reviews of athletes about the effectiveness of Arimidex, we can conclude that it is a fairly effective drug that allows you to eliminate gynecomastia in just a few days. As for the development of side effects, they occur quite rarely and with a decrease in dosages or complete withdrawal of the drug are easily eliminated.
Composition and release form of the drug
Arimidex is an active ingredient with antitumor properties. The concentration and composition of additional components depends on the manufacturer. Usually, milk sugar, polyvinylpyrrolidone K25, sodium dodecyl sulfate, sodium starch glycolate A, calcium salt of stearic acid are present in tablet form. A special shell facilitates the absorption of the substance in the digestive tract.
Arimidex is available in tablet form.
The action of Arimidex
According to the classification, the drug belongs to anticancer drugs of hormonal action. The active ingredient suppresses the production of estrogen in the body. Disrupts the work of the enzyme responsible for the formation of the hormone in the body of postmenopausal women. The medicinal effect is due to a decrease in the level of estradiol in the blood to eighty percent. The usual doses do not affect the formation of cortisol and aldosterone, therefore, compensation for the action of corticosteroids is not required.
A malignant neoplasm of the glandular tissue of the breast can spread faster under the influence of female hormones, since normally the tissue of this organ also responds to the action of estrogens. Suppression of hormone production can worsen tumor growth in postmenopausal women.
General hormonal influences can cause adverse reactions. Other side effects are also possible. Some patients develop a sensitivity of immunity to the substances that make up the tablets. Before therapy, the doctor must rule out allergies and intolerances.
Main adverse reactions:
1. Nervous system: cephalalgia, daytime sleepiness, carpal tunnel syndrome in patients with a predisposition to the disease.
2. Digestive system: lack of appetite, exhaustion of the body, urge to vomit, abdominal discomfort, loose stools.
3. Reproductive system: dryness of the vaginal mucosa, vaginal hemorrhage (often after discontinuation of therapy or replacement of the drug).
4. Skin: rashes, itching, hair loss, erythema reactions, Stevens-Johnson syndrome.
5. Metabolism: increased blood cholesterol levels, imbalance in the mineral components of bone tissue with a decrease in bone density, bone fractures.
6. Liver and biliary tract: increased levels of liver enzymes, increased levels of bilirubin, inflammation of the liver tissue.
7. Allergic manifestations: anaphylactoid effects, Quincke's edema, anaphylactic shock, urticaria, and other reactions.
8. Others: joint pain, stenosing thromsynovitis, congestion to the facial area, general weakness, fatigue.
The doctor monitors the patient's condition at all stages of treatment. If you experience adverse reactions, you need to get advice.
Assimilation and elimination of the drug from the body
Oral administration is accompanied by good absorption of the drug. The chemical is transported into the bloodstream. The maximum concentration of the active component in the blood after oral administration develops within 120 minutes if the patient took the pill on an empty stomach. Food slightly slows down absorption, but does not affect the bioavailability of the substance. The rate of binding of the drug to blood proteins is forty percent. The substance is modified in the liver tissue with the formation of metabolites. The main metabolite does not show therapeutic activity.
The drug is excreted from the body by the kidneys within three days after ingestion. Moderate violations of the kidneys and liver do not affect the excretion of the substance.
Indications for use of Arimidex 1 mg
Malignant neoplasm of the glandular tissue of the breast in women is the main indication. The drug is prescribed by an oncologist in a specific scheme. The remedy is especially effective in the postmenopausal period due to its specific mechanism of action. The therapy suppresses the growth of the pathological focus. Often used in conjunction with chemotherapy and other cancer treatments. Not usually considered first-line treatment for breast cancer. It is more often prescribed if the use of tamoxifen has ended with the further development of the disease.
The main indications for the use of the drug
|1||Postoperative treatment of malignant neoplasm of glandular tissue of the breast with the presence of hormonal receptors in postmenopausal patients. At the initial stage of the development of the disease.|
|2||The second line of drug therapy of late stages of malignant neoplasm of the glandular tissue of the breast that develops after taking tamoxifen.|
|3||Therapy of the first line of local spread of malignant neoplasm of the breast with cell sensitivity to estrogen or unknown hormonal sensitivity in the postmenopausal period.|
The drug is not prescribed to all women. Some patients may experience serious complications during therapy. The main limitation to use is the sensitivity of immunity to the components of the tablet form (allergy).
1. Children's age.
2. The period before menopause.
3. Carrying a baby.
4. Severe liver dysfunction.
5. The period of breastfeeding.
6. Concomitant use of tamoxifen or estrogen-based medications.
The oncologist conducts therapy with caution in the presence of the following factors: non-assimilation of glucose or galactose, progressive disease of bone tissue with a decrease in its density, increased blood cholesterol levels, coronary heart disease, severe impairment of the renal tissue (creatinine clearance rate is less than twenty milliliters per minute), disruption of the liver tissue, lactase deficiency, milk sugar intolerance.
Instructions for the use of Arimidex
The medicine is prescribed by the oncologist after studying the anamnesis, conducting examinations and making a diagnosis. Usually, the drug is used as monotherapy. The tablet form is intended for oral administration. The tablets must be taken whole and washed down with a little water. It is important to take the product every day as directed by a specialist at the same time.
The applications are described for reference purposes. During treatment, the patient should be guided by the instructions of the attending physician and official instructions.
|Scheme of taking pills|
|1. Adults and older women: 1 mg once a day. Long-term reception. Possible therapy for five years.|
|2. Women with impaired renal function: the same regimen without dosage adjustment.|
|3. Women with moderate hepatic impairment also do not need to change the dosage.|
When signs of further development of the disease appear during therapy, taking the pills is stopped.
1. Medicines based on estrogen reduce the therapeutic effect of the drug. Joint use is contraindicated.
2. Arimidex is not used together with tamoxifen due to the decrease in the effectiveness of drug therapy.
3. Clinically important effects of interaction with drugs that affect cytochrome P450 are unlikely. Other effects of interaction with anticancer substances have not been identified.
4. If the endocrine state of the patient is not clear, it is necessary to assess the level of hormones in the blood using laboratory tests.
5. If vaginal hemorrhages appear during therapy, a gynecological examination is performed.
6. In women with a history of osteoporosis or a predisposition to this pathology, the level of bone density is assessed using special examinations. If necessary, preventive and therapeutic measures are prescribed.
7. If the malignant neoplasm is not sensitive to estrogens and does not respond to the use of tamoxifen, anastrozole is not prescribed.
8. The medicine can reduce the speed of psychomotor reactions. You need to drive the vehicle with care.
9. Dangerous effects of overdose have not been found during studies. If there was an accidental intake of a large dosage, you need to contact your doctor.
Full (official) instructions can be found in the package.
Analogs of the drug
Arimidex is the name of the active ingredient and the trade name in tablet form. Other medicines based on this chemical compound can be purchased at the pharmacy.
Analogs may differ in composition and effectiveness. The use of medicines with the same active substance is possible with the permission of the attending physician.
Reviews and prices for the drug
It is not recommended to evaluate the effectiveness of serious medicines according to patient reviews, since anticancer medicines are prescribed only by oncologists as part of life-saving drug therapy. Experts speak well of the properties of the medicine. There is a lower risk of serious complications while taking the pills compared to other anticancer drugs.
The average price for thirty tablets is $ 250.
Arimidex is an effective drug with antitumor activity. It is used to treat breast cancer in postmenopausal women.
The advantages of buying the drug Arimidex 1 mg by the Internet
It can be difficult to order your medicine online for the first time, because this is a new task for you. But most people quickly get used to shopping online, this primarily helps to save time and money. Convenient stores have more expenses for renting premises, paying for utilities, salaries of employees, and therefore the prices in them are usually higher than on the Internet.
Another advantage is a large selection of drugs, while in order to study the entire range from different sellers, you do not need to travel from one end of the city to another or even to a neighboring settlement. It is also convenient to compare prices and other terms. As a result, you can make a profitable purchase in 15 - 20 minutes instead of 3 hours of walking around the trading floors.
You can also quickly find reviews of almost all drugs and marketplaces. They, of course, you also need to be able to filter them, but in general it helps a lot to find quality drugs and reliable online pharmacies.