Cost of Cordarone tablets
Cordarone 250mg price
| Package | Per Pill | Total Price | Save |
|---|---|---|---|
| 250mg × 30 Pills | $4.51 | $135.33
+ Bonus - 4 Pills |
- |
| 250mg × 60 Pills | $4.29 | $257.34
+ Bonus - 4 Pills
Free Trackable Delivery |
$13.20 |
| 250mg × 120 Pills | $4.18 | $501.34
+ Bonus - 7 Pills
Free Trackable Delivery |
$39.60 |
Cordarone 200mg price
| Package | Per Pill | Total Price | Save |
|---|---|---|---|
| 200mg × 30 Pills | $2.18 | $65.50
+ Bonus - 4 Pills |
- |
| 200mg × 60 Pills | $1.59 | $95.63
+ Bonus - 4 Pills |
$35.40 |
| 200mg × 90 Pills | $1.40 | $125.77
+ Bonus - 7 Pills |
$70.20 |
| 200mg × 120 Pills | $1.30 | $155.90
+ Bonus - 7 Pills |
$105.60 |
| 200mg × 180 Pills | $1.20 | $216.15
+ Bonus - 11 Pills
Free Trackable Delivery |
$176.40 |
Cordarone 100mg price
| Package | Per Pill | Total Price | Save |
|---|---|---|---|
| 100mg × 30 Pills | $1.66 | $49.90
+ Bonus - 4 Pills |
- |
| 100mg × 60 Pills | $1.35 | $80.74
+ Bonus - 4 Pills |
$18.60 |
| 100mg × 90 Pills | $1.24 | $111.58
+ Bonus - 7 Pills |
$37.80 |
| 100mg × 120 Pills | $1.19 | $142.43
+ Bonus - 7 Pills |
$56.40 |
| 100mg × 180 Pills | $1.13 | $204.12
+ Bonus - 11 Pills
Free Trackable Delivery |
$95.40 |
| 100mg × 270 Pills | $1.10 | $296.66
+ Bonus - 11 Pills
Free Trackable Delivery |
$151.20 |
| 100mg × 360 Pills | $1.08 | $389.19
+ Bonus - 11 Pills
Free Trackable Delivery |
$208.80 |
How to make an order?
Online ordering is a service for customers that allows you to quickly and conveniently purchase the necessary goods in a pharmacy.
- You can place an order on the site at any time. The minimum amount of an online order is unlimited.
- Service support of operators works daily 24 hours a day.
- Delivery of medicines worldwide.
- There are several ways to pay and pick up an order.
- The prices indicated on the website are valid only for online bookings.
- Prices published on the site may differ from prices in city pharmacies.
- When redeeming an online order, you can use a bonus card.
- In case you didn’t find the necessary lukaria, you can make an individual order at the pharmacy
How to buy Cordarone online?
Ordering interfaces are as simple and intuitive as possible. But just in case, we publish detailed instructions - a step-by-step ordering algorithm.
When you create an order on the site, the city of your location is determined automatically. Another region can be selected in the site header.
1. Find the desired drug through the search bar (just type part of the name).
2. Add the drug to the basket, specify the required quantity.
3. Create an order.
Compound
One tablet contains:
- active ingredient: amiodarone hydrochloride 200.0 mg;
- excipients: lactose monohydrate 71.0 mg, corn starch - 66.0 mg, magnesium stearate - 4.6 mg, povidone K90F 6.0 mg, anhydrous colloidal silicon dioxide - 2.4 mg.
Release form
Tablets from white to white with a creamy tint, round, with a break line on one side, bevel from the edges to the break line and beveled on both sides, engraved with a heart symbol above the break line and the number "200" below the break line.
Pharmacotherapeutic group
Antiarrhythmic agent.
Pharmacological properties
Cordarone belongs to class III antiarrhythmic drugs (a class of repolarization inhibitors) and has a unique mechanism of antiarrhythmic action, since in addition to the properties of class III antiarrhythmics (potassium channel blockade), it has the effects of class I antiarrhythmic drugs (sodium channel blockade), class IV antiarrhythmic drugs (calcium channel blockade). ) and non-competitive beta-adrenergic blocking action.
In addition to antiarrhythmic action, it has antianginal, coronary dilating, alpha and beta adrenoblocking effects.
Antiarrhythmic properties
| an increase in the duration of the 3rd phase of the action potential of cardiomyocytes, mainly due to blocking the ion current in potassium channels (the effect of an antiarrhythmic class III according to the Williams classification); |
| a decrease in the automatism of the sinus node, leading to a decrease in the heart rate; |
| non-competitive blockade of alpha and beta adrenergic receptors; |
| deceleration of sinoatrial, atrial and atrioventricular conduction, more pronounced with tachycardia; |
| no changes in ventricular conduction; |
| an increase in refractory periods and a decrease in the excitability of the myocardium of the atria and non-ventricles, as well as an increase in the refractory period of the atrioventricular node; |
| slowing conduction and an increase in the duration of the refractory period in additional bundles of atrioventricular conduction. |
Other effects:
| no negative inotropic effect when taken orally; |
| reduction of oxygen consumption by the myocardium due to a steady decrease in peripheral resistance and heart rate; |
| an increase in coronary blood flow due to a direct effect on the smooth muscles of the coronary arteries; |
| maintaining cardiac output by reducing pressure in the aorta and reducing peripheral resistance; |
| influence on the metabolism of thyroid hormones: inhibition of the conversion of T3 to T4 (thyroxine-5-deiodinase blockade) and blocking the uptake of these hormones by cardiocytes and hepatocytes, leading to a weakening of the stimulating effect of thyroid hormones on the myocardium. |
Therapeutic effects are observed on average one week after the start of the drug (from several days to two weeks). After stopping its intake, amiodarone is determined in the blood plasma for 9 months. The possibility of maintaining the pharmacodynamic action of amiodarone for 10-30 days after its withdrawal should be taken into account.
Indications for use
Prevention of relapses
Prevention of life-threatening ventricular arrhythmias, including ventricular tachycardia and ventricular fibrillation (treatment should be initiated in a hospital with close cardiac monitoring).
Prevention of supraventricular paroxysmal tachycardia:
| treatment of documented attacks of recurrent sustained supraventricular paroxysmal tachycardia in patients with organic heart disease; |
| prevention of documented attacks of recurrent sustained supraventricular paroxysmal tachycardia in patients without organic heart disease, when antiarrhythmic drugs of other classes are not effective or there are contraindications to their use; |
| treatment of documented attacks of recurrent sustained supraventricular paroxysmal tachycardia in patients with Wolff-Parkinson-White syndrome. |
Atrial fibrillation (atrial fibrillation) and atrial flutter.
Prevention of sudden arrhythmic death in high-risk patients.
Patients after a recent myocardial infarction with more than 10 ventricular extrasystoles per hour, clinical manifestations of chronic heart failure and a reduced left ventricular ejection fraction (less than 40%).
Cordarone can be used in the treatment of arrhythmias in patients with ischemic heart disease and / or impaired left ventricular function.
Method of administration and dosage
The drug should be taken only as prescribed by a doctor!
Cordarone tablets are taken orally before meals and washed down with a sufficient amount of water.
Loading ("saturating") dose: different schemes of saturation can be applied.
In the hospital: the initial dose, divided into several doses, ranges from 600-800 mg (up to a maximum of 1200 mg) per day until a total dose of 10 g is reached (usually within 5-8 days).
Outpatient: the initial dose, divided into several doses, ranges from 600 to 800 mg per day until a total dose of 10 g is reached (usually within 10 to 14 days).
Maintenance dose: may vary from 100 to 400 mg/day in different patients. The lowest effective dose should be used according to the individual therapeutic effect.
Since Cordarone has a very long half-life, it can be taken every other day or take breaks in taking it 2 days a week.
The average therapeutic single dose is 200 mg.
The average therapeutic daily dose is 400 mg.
The maximum single dose is 400 mg.
The maximum daily dose is 1200 mg.
Contraindications
Hypersensitivity to iodine, amiodarone or excipients of the drug.
Galactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome (the product contains lactose).
Weak sinus syndrome, sinus bradycardia, sinoatrial blockade in the absence of an installed artificial pacemaker (pacemaker) in the patient (the risk of "stopping" the sinus node).
Atrioventricular block II-III degree, in the absence of an installed artificial pacemaker (pacemaker) in the patient.
Hypokalemia, hypomagnesemia.
Combination with drugs capable of prolonging the QT interval and causing the development of paroxysmal tachycardia, including ventricular "pirouette" tachycardia (see section "Interaction with other drugs"):
- antiarrhythmic drugs: class IA (quinidine, hydroquinidine, disopyramide procainamide);
Class III antiarrhythmic drugs (dofetilide, ibutilide, bretylium tosylate);
- sotalol;
other (non-antiarrhythmic) drugs such as bepridil;
- vincamine;
- some antipsychotics: phenothiazines (chlorpromazine, cyamemazine, levomepromazine, thioridazine, trifluoperazine, fluphenazine), benzamides (amisulpride, sultopride, sulpride, tiapride, veraliprid), butyrophenones (droperidol, haloperidol), sertindole, pimozide;
- cisapride;
- tricyclic antidepressants;
- macrolide antibiotics (in particular, erythromycin when administered intravenously, spiramycin);
- azoles;
antimalarials (quinine, chloroquine, mefloquine,
halofantrine);
- pentamidine with parenteral administration of diphemanil methyl sulfate;
- mizolastin;
- astemizole, terfenadine;
- fluoroquinolones.
Congenital or acquired prolongation of the QT interval
Thyroid dysfunction (hypothyroidism, hyperthyroidism),
Interstitial lung disease.
Pregnancy (except in special cases, see section "Use during pregnancy and lactation").
Lactation period (see section "Use during pregnancy and lactation").
Age up to 18 years (efficacy and safety not established).
Use with caution:
With decompensated or severe chronic (III-IV FC according to the NYHA classification) heart failure, liver failure, bronchial asthma, severe respiratory failure, in elderly patients (high risk of developing severe bradycardia), with atrioventricular block I degree.
Pregnancy and lactation:
Pregnancy.
The currently available clinical information is insufficient to determine whether or not fetal malformations may or may not occur when using amiodarone in the first trimester of pregnancy.
Since the thyroid gland of the fetus begins to bind iodine only from the 14th week of pregnancy (amenorrhea), it is not expected to be affected by amiodarone if it is used earlier. Excess iodine when using the drug after this period can lead to the appearance of laboratory symptoms of hypothyroidism in the newborn or even to the formation of a clinically significant goiter in him.
Due to the effect of the drug on the thyroid gland of the fetus, amiodarone is contraindicated during pregnancy, except in special cases when the expected benefit outweighs the risks (with life-threatening gastric arrhythmias).
The period of breastfeeding
Cordarone is excreted in breast milk in significant amounts, so it is contraindicated during lactation (therefore, during this period, the drug should be discontinued or breastfeeding should be stopped).
Overdose
When ingesting very large doses, several cases of sinus bradycardia, cardiac arrest, attacks of ventricular tachycardia, paroxysmal ventricular "pirouette" tachycardia and liver damage have been described. It is possible to slow down the atrioventricular conduction, increase the already existing heart failure.
Treatment should be symptomatic (gastric lavage, use of activated charcoal (if the drug has been taken recently), in other cases, symptomatic therapy is carried out: for bradycardia - beta-adrenergic stimulators or the installation of a pacemaker, for ventricular "pirouette" tachycardia - intravenous administration of magnesium salts or pacing .
Neither Cordarone nor its metabolites are removed by hemodialysis.
There is no specific antidote.
Conditions for dispensing from pharmacies and shelf life
Storage conditions:
Store at a temperature not exceeding 30C.
Keep out of the reach of children!
Shelf life 3 years
Do not use after the expiration date.
Sold by prescription.
Why can't you take Cordarone for a long time?
With prolonged use of the drug in high daily doses, grayish or bluish pigmentation of the skin may be observed; after stopping treatment, this pigmentation slowly disappears. Other possible adverse reactions Cordarone: digestive disorders (nausea, vomiting, taste disturbances);
Is it possible to drink Cordarone with arrhythmia?
In supraventricular arrhythmias, the most commonly prescribed maintenance dose is 200 mg/day, although the dose may be increased for a short time if paroxysms recur. Quite effective, especially in women with low body weight, can be the use of Cordarone at a dose of 100-200 mg / day 5 times a week.
How long can Cordarone be taken?
The recommended dose is 200 mg (1 tablet) 3 times a day for 8-10 days. In some cases, higher doses (4-5 tablets per day) are used for initial treatment, but always for a short period and under ECG control.
When is the best time to take Cordarone in the morning or in the evening?
The antiarrhythmic drug Cordarone should be taken immediately before meals with plenty of liquid. The maximum dose for outpatient admission is no more than 800 mg (divided into 3-4 doses) per day.