Clinico-pharmacological group:
Antipsychotics.
ATX: N05AA01.
What is Thorazine used for?
Thorazine is a neuroleptic of the group of aliphatic phenothiazine derivatives. It has a pronounced antipsychotic effect, eliminates psychomotor agitation, reduces the feeling of fear, aggressiveness, psychomotor retardation.
How to take Thorazine?
Adults: 25 mg every 4 to 6 hours. Children: For children over 12 years of age, Thorazine is prescribed at 550 mcg / kg (0.55 mg / kg) or 15 mg per 1 m2 of body surface, if necessary, every 4-6 hours.
How much do Thorazine (Chlorpromazine) tablets cost?
Thorazine 100mg price
| Package | Per Pill | Total Price | Save |
|---|---|---|---|
| 100mg × 30 Pills | $1.02 | $30.67
+ Bonus - 4 Pills |
- |
| 100mg × 60 Pills | $0.84 | $50.47
+ Bonus - 4 Pills |
$10.80 |
| 100mg × 90 Pills | $0.77 | $69.37
+ Bonus - 7 Pills |
$22.50 |
| 100mg × 180 Pills | $0.61 | $108.97
+ Bonus - 11 Pills |
$73.80 |
| 100mg × 360 Pills | $0.53 | $189.97
+ Bonus - 11 Pills |
$176.40 |
Thorazine 50mg price
| Package | Per Pill | Total Price | Save |
|---|---|---|---|
| 50mg × 30 Pills | $0.87 | $26.18
+ Bonus - 4 Pills |
- |
| 50mg × 60 Pills | $0.69 | $41.48
+ Bonus - 4 Pills |
$10.80 |
| 50mg × 90 Pills | $0.60 | $54.08
+ Bonus - 7 Pills |
$24.30 |
| 50mg × 120 Pills | $0.56 | $66.68
+ Bonus - 7 Pills |
$37.20 |
| 50mg × 180 Pills | $0.52 | $92.78
+ Bonus - 11 Pills |
$63.00 |
| 50mg × 360 Pills | $0.47 | $170.18
+ Bonus - 11 Pills |
$144.00 |
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Pharmacodynamics:
Thorazine has an antipsychotic effect due to the blockade of dopamine D2 receptors of the mesocortical and mesolimbic systems.
The drug acts as a sedative by blocking the adrenoreceptors of the reticular formation of the brain stem.
It has an antiemetic effect by blocking the dopamine D2 receptors of the trigger zone of the vomiting center.
Thorazine causes hyperthermia by blocking dopamine receptors in the hypothalamus.
It has a moderate antihistamine and M-anticholinergic action. Reduces blood pressure. Raises the pain threshold.
Pharmacokinetics:
After ingestion on an empty stomach, up to 50% of the substance is absorbed in the gastrointestinal tract. The maximum plasma concentration is reached 1-2 hours after intramuscular injection and 2-4 hours after oral administration. Communication with plasma proteins is 99%.
The active substance penetrates the blood-brain and placental barrier, is excreted in breast milk. Metabolism in the liver.
The half-life is from 30 hours to 4 weeks. Elimination with faeces and kidneys in the form of metabolites.
Indications for the use of Thorazine:
The drug is used to treat endogenous psychoses, with alcoholic psychosis, reactive mental disorders. It is used to enhance the action of antihistamines and analgesics. It is used as an antiemetic for Meniere's disease, radiation and chemotherapy. It is used as part of a lytic mixture for the purpose of artificial hypothermia, as well as in the complex treatment of itchy dermatoses.
Contraindications
Angle-closure glaucoma, urinary retention, multiple sclerosis, Parkinson's disease, myasthenia gravis, chronic heart failure, severe liver and kidney failure, arterial hypotension, porphyria, individual intolerance, children under 3 years of age.
Apply with caution:
Rheumatism in the active phase, peptic ulcer of the stomach and duodenum, cholelithiasis and urolithiasis, acute pyelitis, hypersensitivity.
Pregnancy and lactation:
Recommendations for FDA - category C. During pregnancy and lactation, the use of the drug is contraindicated. If it is impossible to stop taking chlorpromazine during pregnancy, minimal maintenance doses are used, with temporary cancellation for the period of childbirth in order to prevent atropine-like effects in newborns.
Method of application and doses:
Use in children
Inside, depending on age and body weight.
3-5 years (body weight not more than 23 kg): 0.55 mg / kg every 6-8 hours, not more than 40 mg per day;
5-12 years (body weight no more than 46 kg): 75 mg per day.
Adults
Inside, 25-100 mg per day for 1-4 doses. If necessary, the dose is increased by 25-50 mg every 3 days until a therapeutic effect is achieved, but should not exceed 1.5 g per day.
The highest daily dose: 1.5 g for oral administration; 150 mg for intramuscular injection and 100 mg for intravenous administration.
The highest single dose: 0.3 g for oral administration; 1 g for intramuscular injection and 250 mg for intravenous administration.
Side effects:
- Central and peripheral nervous system: akathisia, rarely - parkinsonian syndrome, dystonic extrapyramidal reactions, thermoregulation disorders, tardive dyskinesia, in isolated cases, convulsive syndrome develops.
- Hematopoietic system: agranulocytosis, leukopenia.
- Cardiovascular system: tachycardia, hypotension.
- Digestive system: dyspeptic disorders, rarely - cholestatic jaundice.
- Dermatological reactions: photosensitivity, skin pigmentation.
- Sense organs: clouding of the lens, blurred vision.
- Urinary system: urinary retention.
- Reproductive system: menstrual disorders, gynecomastia.
- Local reactions: post-injection infiltrate, phlebitis.
- Allergic reactions.
Overdose:
Arterial hypotension, tachycardia, atrioventricular blockade, depression of consciousness, extrapyramidal symptoms, coma. With prolonged use - toxic hepatitis.
Treatment is symptomatic.
Interaction of Thorazine with other drugs:
With simultaneous use with drugs that depress the central nervous system (hypnotics, benzodiazepines, non-opioid and opioid analgesics, tricyclic antidepressants, anesthetics), the antihypertensive effect and depression of the central nervous system are enhanced.
MAO inhibitors contribute to the development of extrapyramidal disorders (due to a slowdown in the metabolism of Thorazine in the liver).
The absorption of the drug decreases with the simultaneous use of antacids (an interval of 4 hours should be maintained).
Thorazine reduces the effects of levodopa when used simultaneously.
Special instructions:
With prolonged use - monitoring of the blood count, electrocardiogram parameters, liver function, blood pressure.
Excluded the use of alcohol during treatment with Thorazine and within 5 days after discontinuation of the drug.
With the appearance of hyperthermia, it is recommended to cancel the drug.
During treatment, driving vehicles and working with moving mechanisms is not recommended.